The researchers spontaneously studied mice to eat dough containing THC, the main psychoactive component of marijuana edibles. This opens the door to further research that sheds light on the behavioral and physiological effects of eating marijuana-rich foods in humans.
This study was one of the first to report on spontaneous oral THC use in animals in a manner similar to the way people take drugs.
In a recent article on drug and alcohol dependence, IUPUI and Indiana University Bloomington researchers found that mice had less activity and lower body temperature after eating edible THC. The researchers also found that the effects of edible THC vary depending on the sex of the subject, said Michael Smoker, senior author of the study and doctor of addiction neuroscience. Candidate of Stephen Boehm professor’s laboratory of IUPUI’s Psychology. The Addiction Neuroscience Graduate Program is IUPUI’s Purdue University program.
The study revealed that mice consume self-administered or spontaneously consumed edible THC and repeat it. Mice gradually increased dose in flour, sugar, salt, glycerol and THC dough.
As marijuana is becoming more popular in legalized states, it is important to understand the health impact of marijuana use, Smoker said.
“People can buy biscuits, sweets and all sorts of things with THC.” You have to make your own brownies or something and now it’s becoming more widely available and gaining popularity, “he said.
Smokers said marijuana food can cause serious side effects. Many commercially manufactured marijuana based products have a relatively higher THC concentration than marijuana plant materials. In some cases, people do not know how much marijuana to eat, and eventually they eat more than they eat.
One of the questions researchers want to answer is how food affects people’s ability to think about the long-term consequences of a person who eats and stops repeatedly, and the effect is on children. Said to eat.
The researchers used mice in the study for questions about edible THCs based on ethical barriers with regard to human use and lack of control over prior exposure to human THC and other drugs.
In previous studies, mice were used to study the effects of marijuana. But according to smokers, it is very difficult for people to find a way to administer the drug themselves.
The co-author of the paper is Ken Mackie, Department of Psychology and Brain Sciences, and the Way Center of IU Bloomington. Christopher Lapish of IUPUI’s Psychology and Indiana Alcohol Research Center; Stephen Boehm II with IUPUI’s Psychology and Indiana Alcohol Institute. Boehm is also a fund investigator for the IU Addiction Grand Challenge Initiative.
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